General Information

  • ID:  hor003066
  • Uniprot ID:  NA
  • Protein name:  Neurotensin
  • Gene name:  NA
  • Organism:  Mus musculus
  • Family:  Neurotensin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  ELYENKPRRPYIL
  • Length:  13
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  YES
  • Target:  NA
  • Target Unid:  NA
  • IC50: binding affinities for hNTR-1 (IC50 = 0.4 ± 0.1 nM), binding affinities for hNTR-2 (IC50 = 4.0 ± 1.1 nM), binding affinities for hNTR-2 (IC50 = 440 ± 14 nM),
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: 5.9±0.2 minute; /354 seconds ( PubMed ID: 12954066 )

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003066_AF2.pdbhor003066_ESM.pdb

Physical Information

Mass: 190517 Formula: C78H123N21O21
Absent amino acids: ACDFGHMQSTVW Common amino acids: ELPRY
pI: 9.14 Basic residues: 3
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -131.54 Boman Index: -4117
Half-Life: 1 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 90
Instability Index: 8373.85 Extinction Coefficient cystines: 2980
Absorbance 280nm: 248.33

Literature

  • PubMed ID:  20412386##12954066
  • Title:  Analysis of Peptides in Prohormone Convertase 1/3 Null Mouse Brain Using Quantitative Peptidomics